Ethyl Acetoacetate → 3-Allyl-6-methyluracil

HRID 396998

反応式

HRID 396998 の反応式
[CH2:1]([NH:4][C:5]([NH2:7])=[O:6])[CH:2]=[CH2:3].[C:8](OCC)(=[O:13])[CH2:9][C:10]([CH3:12])=O.[OH-].[K+]>C(O)C.Cl.CO>[CH2:1]([N:4]1[C:8](=[O:13])[CH:9]=[C:10]([CH3:12])[NH:7][C:5]1=[O:6])[CH:2]=[CH2:3]

参加物

7

反応物 3

HCID 8868Ethyl AcetoacetateHCID 11181AllylureaHCID 14797Potassium Hydroxide

生成物 1

HCID 136020473-Allyl-6-methyluracil

試薬・触媒・溶媒 3

HCID 313Hydrochloric Acid触媒HCID 702Ethanol溶媒HCID 887Methanol溶媒

実験手順

To allylurea (25 g, 0.25 mol) in ethanol (10 mL) was added ethyl acetoacetate (31.86 mL, 0.25 mol) and 10 drops conc. HCl. After 12 days at room temperature, concentration gave an oil which was dissolved in MeOH. KOH (22.5 g, 0.34 mol) was added and the solution refluxed for 1 hour. After neutralization, the resulting solid 1 was collected. Yield 2.7 g (7%). NMR (CDCl3) δ: 2.16 (3H, s), 4.52 (2H, d), 5.18 (1H, d), 5.23 (1H, d), 5.60 (1H, s), 5.82-5.93 (1H, m), 10.3 (1H, s).

後処理

  1. concentrationconcentration
  2. customgave an oil which
  3. temperaturethe solution refluxed for 1 hour
  4. customAfter neutralization, the resulting solid 1 was collected

出典と根拠

ORDレコード
ord-0b659837c93541b1a1830af60c6126e1
出典データセット
uspto-grants-2003_08
特許番号
US06608197B2

関連ノート

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