Potassium Carbonate → 6-Methoxy-1-piperidin-4-yl-3,4-dihydro-isoquinoline

HRID 397062

反応式

HRID 397062 の反応式
FC(F)(F)C([N:5]1[CH2:10][CH2:9][CH:8]([C:11]2[C:20]3[C:15](=[CH:16][C:17]([O:21][CH3:22])=[CH:18][CH:19]=3)[CH2:14][CH2:13][N:12]=2)[CH2:7][CH2:6]1)=O.C([O-])([O-])=O.[K+].[K+]>>[CH3:22][O:21][C:17]1[CH:16]=[C:15]2[C:20](=[CH:19][CH:18]=1)[C:11]([CH:8]1[CH2:9][CH2:10][NH:5][CH2:6][CH2:7]1)=[N:12][CH2:13][CH2:14]2

参加物

3

反応物 2

HCID 11430Potassium CarbonateHCID 181723932,2,2-Trifluoro-1-[4-(6-methoxy-3,4-dihydro-isoquinolin-1-yl)-piperidin-1-yl]-ethanone

生成物 1

HCID 181723896-Methoxy-1-piperidin-4-yl-3,4-dihydro-isoquinoline収率 88%

実験手順

To a stirred solution of 2,2,2-trifluoro-1-[4-(6-methoxy-3,4-dihydro-isoquinolin-1-yl)-piperidin-1-yl]-ethanone (0.160 g, 0.470 mmol) was added a solution of 10% K2CO3 (2 ml). The cloudy mixture was stirred at RT overnight. The reaction mixture was extracted with EtOAc (3×5 ml), the combined organic extracts were washed with brine (1×5 ml), dried over MgSO4, filtered, and concentrated in vacuo to give the desired compound as a yellow oil (0.101 g, 0.413 mmol, 88% yield).

後処理

  1. extractionThe reaction mixture was extracted with EtOAc (3×5 ml)
  2. washthe combined organic extracts were washed with brine (1×5 ml)
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-0f54e75af8fb40c3914a95cb1a911680
出典データセット
uspto-grants-2003_08
特許番号
US06608203B2

関連ノート

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