化工社化工社 化学情報印刷レポート · 研究参考用
Cortisol → Hydrocortisone 4-bromobutanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cortisol | HCID 5754 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Bromobutyryl chloride | HCID 70225 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | Hydrocortisone 4-bromobutanoate | HCID 86606384 | — |
反応手順
Five portions of 4-bromobutanoylchloride (0.35 ml×5) and potassium carbonate (0.4 g×5) were added in 24 hours to a solution of hydrocortisone (1 g) in CHCl3 dried over P2O5 and stirred for 5 days. The solution was treated with water, the organic phase was separated, dried (Na2SO4) and deprived of the solvent at reduced pressure.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06610676B1 |
| 出典データセット | uspto-grants-2003_08 |
| ORD ID | ord-df776e41bca7483791702b15ebb337ba |
| 出典メモ | uspto-grants-2003_08 |