Hydrochloric Acid → (S)-2-(6-cyclopropoxy-2,3-dihydro-1H-3a-aza-cyclopenta[a]inden-8-yl)-1-methyl-ethylamine hydrochloride

HRID 397322ノート

反応式

HRID 397322 の反応式
C(OC(=O)[NH:7][C@@H:8]([CH3:26])[CH2:9][C:10]1[C:18]2[CH:17]=[C:16]([O:19][CH:20]3[CH2:22][CH2:21]3)[CH:15]=[CH:14][C:13]=2[N:12]2[CH2:23][CH2:24][CH2:25][C:11]=12)(C)(C)C.[ClH:28]>C(OCC)(=O)C>[ClH:28].[CH:20]1([O:19][C:16]2[CH:15]=[CH:14][C:13]3[N:12]4[CH2:23][CH2:24][CH2:25][C:11]4=[C:10]([CH2:9][C@@H:8]([NH2:7])[CH3:26])[C:18]=3[CH:17]=2)[CH2:21][CH2:22]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 69363623(S)-[2-(6-cyclopropoxy-2,3-dihydro-1H-3a-aza-cyclopenta[a]inden-8-yl)-1-methyl-ethyl]-carbamic acid tert-butyl ester

生成物 1

HCID 21355889(S)-2-(6-cyclopropoxy-2,3-dihydro-1H-3a-aza-cyclopenta[a]inden-8-yl)-1-methyl-ethylamine hydrochloride

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒2 回

実験手順

A solution of 11.81 g (S)-[2-(6-cyclopropoxy-2,3-dihydro-1H-3a-aza-cyclopenta[a]inden-8-yl)-1-methyl-ethyl]-carbamic acid tert-butyl ester in 120 mL of a 2.26 M solution of hydrochloric acid in ethyl acetate was stirred at room temperature for 2 h. The resulting suspension was diluted with 120 mL ethyl acetate and the product collected by filtration, washed with ethyl acetate and dried to constant weight under high vacuum to yield 8.65 g (S)-2-(6-cyclopropoxy-2,3-dihydro-1H-3a-aza-cyclopenta[a]inden-8-yl)-1-methyl-ethylamine hydrochloride as white crystals melting at 214-217° C.

後処理

  1. filtrationthe product collected by filtration
  2. washwashed with ethyl acetate
  3. customdried to constant weight under high vacuum

出典と根拠

ORDレコード
ord-cae8b87ba305480e97f6a9ed922b281e
出典データセット
uspto-grants-2003_08
特許番号
US06610685B2

反応ノート

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