化工社化工社 化学情報印刷レポート · 研究参考用
Water → Methyl 2-(methylamino)-2-phenylacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Methanamine, hydrochloride (1:1) | HCID 11637 | — |
| 反応物 | Benzeneacetic acid, alpha-bromo-, methyl ester | HCID 137806 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 触媒 | Benzyl triethylammonium chloride | HCID 66133 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Methyl 2-(methylamino)-2-phenylacetate | HCID 13852358 | 71.2% |
反応手順
In this example a mixture containing 30.7 g of methyl bromo-phenylacetate, 36.2 g of methyl ammonium chloride (i.e. CH3NH3Cl); 3.0 g of benzyltriethylammonium chloride and 67.5 g of sodium bicarbonate in about 300 ml of methylene chloride (and about 25 ml of water) was warmed to refluxed and refluxed for about 18 hours. The mixture was then cooled and washed three times with water, dried over magnesium sulfate and concentrated by vacuum evaporation affording 17.1 g of the title compound as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04723031 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-c156814239954cc794d18661347d1e7d |
| 出典メモ | uspto-grants-1988_02 |