Ammonia → (2-(1H-IMIDAZOL-2-YL)PHENYL)METHANAMINE

HRID 397503ノート

反応式

HRID 397503 の反応式
[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=1[C:8]#[N:9].N>C(O)C.[Ni]>[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=1[CH2:8][NH2:9]

参加物

5

反応物 2

HCID 222AmmoniaHCID 114010062-(1H-imidazol-2-yl)benzonitrile

生成物 1

HCID 11171256(2-(1H-IMIDAZOL-2-YL)PHENYL)METHANAMINE

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

A solution of 2-(1H-imidazol-2-yl)-benzonitrile (50 mg, 0.30 mmol) in ethanol saturated with ammonia (5 ml) was stirred in the presence of Raney nickel (50% slurry in water, washed with ethanol, catalytic amount) under a hydrogen atmosphere for 2 h. The reaction mixture was filtered over celite and concentrated to give 2-(1H-imidazol-2-yl)-benzylamine; 1H NMR (CDCl3, 400 MHz) δ8.13 (d, 1H, J=7.5 Hz), 7.42 (m, 1H), 7.28 (m, 2H), 7.18 (bs, 2H), 3.96 (s, 2H).

後処理

  1. filtrationThe reaction mixture was filtered over celite and
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-da32d38fc1e54eb886842729c458ab9e
出典データセット
uspto-grants-2003_08
特許番号
US06610701B2

反応ノート

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