Ammonia → 2-(1-Tetrazolyl)benzylamine

HRID 397515ノート

反応式

HRID 397515 の反応式
[N:1]1([C:6]2[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=2[C:8]#[N:9])[CH:5]=[N:4][N:3]=[N:2]1.N>C(O)C.[Ni]>[N:1]1([C:6]2[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=2[CH2:8][NH2:9])[CH:5]=[N:4][N:3]=[N:2]1

参加物

5

反応物 2

HCID 222AmmoniaHCID 218662732-(1H-Tetrazol-1-YL)benzonitrile

生成物 1

HCID 111596142-(1-Tetrazolyl)benzylamine

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

A solution of 2-Tetrazol-1-yl-benzonitrile (1.3 g, 7.6 mmol) in ethanol saturated with ammonia (125 ml) was stirred in the presence of Raney nickel (50% slurry in water, washed with ethanol, catalytic amount) under a hydrogen atmosphere overnight. The reaction mixture was filtered over celite and concentrated to give 2-Tetrazol-1-yl-benzylamine; 1H NMR (CDCl3, 400 MHz) δ9.28 (s, 1H), 7.59 (m, 2H), 7.47 (m, 2H), 3.70 (s, 2H).

後処理

  1. filtrationThe reaction mixture was filtered over celite and
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-312f3bb1713b49e68ef2c9ab3ea52b0c
出典データセット
uspto-grants-2003_08
特許番号
US06610701B2

反応ノート

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