1H-Benzo[d]imidazole-2-sulfonyl chloride → HCID 57267114、化合物

反応式

Cl.[NH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[C:8]1[N:12]=[C:11]([CH2:13][O:14][C:15]2[CH:32]=[CH:31][C:18]([CH2:19][N:20]3[C:28](=[O:29])[C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[C:21]3=[O:30])=[CH:17][CH:16]=2)[O:10][N:9]=1.[NH:33]1[C:37]2[CH:38]=[CH:39][CH:40]=[CH:41][C:36]=2[N:35]=[C:34]1[S:42](Cl)(=[O:44])=[O:43]>>[NH:33]1[C:37]2[CH:38]=[CH:39][CH:40]=[CH:41][C:36]=2[N:35]=[C:34]1[S:42]([N:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[C:8]1[N:12]=[C:11]([CH2:13][O:14][C:15]2[CH:32]=[CH:31][C:18]([CH2:19][N:20]3[C:21](=[O:30])[C:22]4[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=4)[C:28]3=[O:29])=[CH:17][CH:16]=2)[O:10][N:9]=1)(=[O:43])=[O:44]

参加物

反応物 2

HCID 110638611H-Benzo[d]imidazole-2-sulfonyl chloride

HCID 699488362-[4-(3-[(2S)-2-piperidyl]-1,2,4-oxadiazol-5-ylmethoxy)benzyl]-1,3-isoindolinedione hydrochloride

生成物 1

HCID 57267114HCID 57267114、化合物

実験手順

The title compound was prepared by a similar method to Example 1 from 2-[4-(3-[(2S)-2-piperidyl]-1,2,4-oxadiazol-5-ylmethoxy)benzyl]-1,3-isoindolinedione hydrochloride [see Preparation 15] and 1H-benzo[d]imidazole-2-sulfonyl chloride [see Preparation 8] to afford 2-[4-(3-[(2S)-1-(1H-benzo[d]imidazol-2-ylsulfonyl)-2-piperidyl]-1,2,4-oxadiazol-5-ylmethoxy)benzyl]-1,3-isoindolinedione (956 mg).

出典と根拠

ORDレコード: ord-6b21338586c54d15bc30a628973d4f2a
出典データセット: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06610707B1

反応ノート

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