N'1-[((2S)-1-[(4-fluorophenyl)sulfonyl]-2-piperidylcarbonyl)oxy]ethanimidamide → (2S)-1-[(4-fluorophenyl)sulfonyl]-2-(3-methyl-1,2,4-oxadiazol-5-yl)piperidine

HRID 397640ノート

反応式

HRID 397640 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][C@H:12]2[C:17]([O:19][N:20]=[C:21]([NH2:23])[CH3:22])=O)(=[O:10])=[O:9])=[CH:4][CH:3]=1>C1(C)C(C)=CC=CC=1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][C@H:12]2[C:17]2[O:19][N:20]=[C:21]([CH3:22])[N:23]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

参加物

3

反応物 1

HCID 86759129N'1-[((2S)-1-[(4-fluorophenyl)sulfonyl]-2-piperidylcarbonyl)oxy]ethanimidamide

生成物 1

HCID 52104633(2S)-1-[(4-fluorophenyl)sulfonyl]-2-(3-methyl-1,2,4-oxadiazol-5-yl)piperidine

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

The title compound was prepared by a similar method to Preparation 6 from N′1-[((2S)-1-[(4-fluorophenyl)sulfonyl]-2-piperidylcarbonyl)oxy]ethanimidamide [see Preparation 82] and xylene. The crude product was purified by column chromatography on silica gel eluting with a solvent gradient of 100:0 changing to 80:20, by volume, hexane:ethyl acetate in 10% increments, to afford (2S)-1-[(4-fluorophenyl)sulfonyl]-2-(3-methyl-1,2,4-oxadiazol-5-yl)piperidine as an oil.

後処理

  1. customThe crude product was purified by column chromatography on silica gel eluting with a solvent gradient of 100:0 changing to 80:20, by volume, hexane

出典と根拠

ORDレコード
ord-4ac1838502054db385a382963e4a11aa
出典データセット
uspto-grants-2003_08
特許番号
US06610707B1

反応ノート

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