p-Bromobenzenesulfonyl chloride → HCID 23000994、化合物

HRID 397715

反応式

HRID 397715 の反応式
[CH:1]1([CH2:6][CH2:7][CH2:8][OH:9])[CH2:5][CH2:4][CH2:3][CH2:2]1.C(N(CC)CC)C.[Br:17][C:18]1[CH:23]=[CH:22][C:21]([S:24](Cl)(=[O:26])=[O:25])=[CH:20][CH:19]=1>ClCCl.Cl>[Br:17][C:18]1[CH:23]=[CH:22][C:21]([S:24]([O:9][CH2:8][CH2:7][CH2:6][CH:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)(=[O:26])=[O:25])=[CH:20][CH:19]=1

参加物

6

反応物 3

HCID 7396p-Bromobenzenesulfonyl chlorideHCID 8471TriethylamineHCID 69842Cyclopentanepropanol

生成物 1

HCID 23000994HCID 23000994、化合物収率 83.1%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 6344Dichloromethane溶媒

実験手順

To a solution of 3-cyclopentyl-1-propanol (2.0 g, 15.6 mmol) in triethylamine (3.25 ml, 23.4 mmol) and dichloromethane (50 ml) was added 4-bromobenzenesulfonyl chloride (4.4 g, 17.6 mmol). The solution was stirred for 16 h, diluted with 2 N aqueous hydrochloric acid (100 ml) and extracted with dichloromethane (100 ml). The extract was washed with saturated aqueous sodium hydrogen carbonate solution (100 ml) and brine (100 ml), dried (MgSO4) and concentrated in vacuo to give the title compound as a white crystalline solid (4.50 g, 80%).

後処理

  1. extractionextracted with dichloromethane (100 ml)
  2. washThe extract was washed with saturated aqueous sodium hydrogen carbonate solution (100 ml) and brine (100 ml)
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-71e6cd67d026411793d852f7d654c0d8
出典データセット
uspto-grants-2003_08
特許番号
US06610711B2

関連ノート

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