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Acetic Acid → HCID 23445088、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Ethyl orthoformate | HCID 31214 | — |
| 反応物 | Ethyl nitroacetate | HCID 69379 | — |
| 反応物 | 5-Amino-2,2-difluoro-1,3-benzodioxole | HCID 2736893 | — |
| 触媒 | Iron | HCID 23925 | — |
| 生成物 | HCID 23445088 | HCID 23445088 | — |
反応手順
Following the general method described in example 293, 2,2-difluoro-benzo[1,3]dioxol-5-ylamine was reacted with triethyl orthoformate, ethyl nitroacetate and acetic acid followed by treatment with triethyl orthoformate, iron and acetic acid and subsequent alkaline hydrolysis. The isolated acid was directly reduced according to example 264, by reaction with BH3 THF complex followed by hydrolytic workup and the title compound was obtained as a light brown solid. Mp. 163-164° C. (H2O), MS: m/e=254 (M+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06610723B2 |
| 出典データセット | uspto-grants-2003_08 |
| ORD ID | ord-65ecd3d8357344cfb9ddc7bccd520302 |
| 出典メモ | uspto-grants-2003_08 |