Acetic Acid → HCID 23445088、化合物

HRID 397936

反応式

HRID 397936 の反応式
[F:1][C:2]1([F:12])[O:6][C:5]2[CH:7]=[CH:8][C:9]([NH2:11])=[CH:10][C:4]=2[O:3]1.C([O:20][CH2:21][CH3:22])(OCC)OCC.[N+:23]([CH2:26]C(OCC)=O)([O-])=O.[C:32](O)(=O)C>[Fe]>[F:12][C:2]1([F:1])[O:6][C:5]2[CH:7]=[CH:8][C:9]([N:11]3[CH:32]=[C:22]([CH2:21][OH:20])[N:23]=[CH:26]3)=[CH:10][C:4]=2[O:3]1

参加物

6

反応物 4

HCID 176Acetic Acid2 回HCID 31214Ethyl orthoformate2 回HCID 69379Ethyl nitroacetateHCID 27368935-Amino-2,2-difluoro-1,3-benzodioxole

生成物 1

HCID 23445088HCID 23445088、化合物

試薬・触媒・溶媒 1

HCID 23925Iron触媒

実験手順

Following the general method described in example 293, 2,2-difluoro-benzo[1,3]dioxol-5-ylamine was reacted with triethyl orthoformate, ethyl nitroacetate and acetic acid followed by treatment with triethyl orthoformate, iron and acetic acid and subsequent alkaline hydrolysis. The isolated acid was directly reduced according to example 264, by reaction with BH3 THF complex followed by hydrolytic workup and the title compound was obtained as a light brown solid. Mp. 163-164° C. (H2O), MS: m/e=254 (M+).

後処理

  1. customThe isolated acid was directly reduced according to example 264, by reaction with BH3 THF complex

出典と根拠

ORDレコード
ord-65ecd3d8357344cfb9ddc7bccd520302
出典データセット
uspto-grants-2003_08
特許番号
US06610723B2

関連ノート

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