Phenol → Di-tert-butyl ether

HRID 398022

反応式

HRID 398022 の反応式
[C:1]1([OH:7])[CH:6]=CC=C[CH:2]=1.CNC(=NC)O[C:12]([CH3:15])([CH3:14])[CH3:13].[C:18](OCC)(=O)C.CCCCCC>>[C:12]([O:7][C:1]([CH3:2])([CH3:6])[CH3:18])([CH3:15])([CH3:14])[CH3:13]

参加物

4

反応物 3

HCID 996PhenolHCID 21226206Ethyl acetate hexaneHCID 23001675N,N'-dimethyl-O-t-butylisourea

生成物 1

HCID 22541Di-tert-butyl ether収率 15%

実験手順

Following a procedure analogous to (3b), the phenol from (3a) (270 mg, 0.97 mmol) was reacted with N,N′-dimethyl-O-t-butylisourea. Silica gel chromatography (ethyl acetate-hexane, 20:80) gave the t-butyl ether (50.2 mg, 15%) as a 1:1 mixture of two isomers. MS found: (M+H)+=334.

出典と根拠

ORDレコード
ord-06a1d31e4388451ab0e3ab6eef91a634
出典データセット
uspto-grants-2003_08
特許番号
US06610731B2

関連ノート

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