Methanol → Methyl 2-((4-hydroxyphenyl)amino)acetate

HRID 398023

反応式

HRID 398023 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]([OH:12])=[O:11])=[CH:4][CH:3]=1.[CH3:13]O>>[CH3:13][O:11][C:10](=[O:12])[CH2:9][NH:8][C:5]1[CH:6]=[CH:7][C:2]([OH:1])=[CH:3][CH:4]=1

参加物

3

反応物 2

HCID 887MethanolHCID 67149N-(4-Hydroxyphenyl)glycine

生成物 1

HCID 422581Methyl 2-((4-hydroxyphenyl)amino)acetate収率 99%

実験手順

The p-hydroxy phenyl glycine (74.0 g, 442 mmol) was suspended in methanol (500 mL), cooled in an ice bath and HCl (gas) was bubbled through the reaction mixture for 20 minutes, to give a clear solution. The reaction was stirred at rt for 48 h, concentrated in vacuo to give an oil which was triturated with ethyl ether to give the p-hydroxy phenyl glycine methyl ester (95.8 g, 99%) as a white powder. MS found: (M+H)+=182.

後処理

  1. temperaturecooled in an ice bath
  2. customHCl (gas) was bubbled through the reaction mixture for 20 minutes
  3. customto give a clear solution
  4. concentrationconcentrated in vacuo
  5. customto give an oil which
  6. customwas triturated with ethyl ether

出典と根拠

ORDレコード
ord-49d8304cdbec4ea2a75f2c2f5b3084f4
出典データセット
uspto-grants-2003_08
特許番号
US06610731B2

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