Methanol → Methyl 2-((4-hydroxyphenyl)amino)acetate
反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]([OH:12])=[O:11])=[CH:4][CH:3]=1.[CH3:13]O>>[CH3:13][O:11][C:10](=[O:12])[CH2:9][NH:8][C:5]1[CH:6]=[CH:7][C:2]([OH:1])=[CH:3][CH:4]=1参加物
3
実験手順
The p-hydroxy phenyl glycine (74.0 g, 442 mmol) was suspended in methanol (500 mL), cooled in an ice bath and HCl (gas) was bubbled through the reaction mixture for 20 minutes, to give a clear solution. The reaction was stirred at rt for 48 h, concentrated in vacuo to give an oil which was triturated with ethyl ether to give the p-hydroxy phenyl glycine methyl ester (95.8 g, 99%) as a white powder. MS found: (M+H)+=182.
後処理
- temperaturecooled in an ice bath
- customHCl (gas) was bubbled through the reaction mixture for 20 minutes
- customto give a clear solution
- concentrationconcentrated in vacuo
- customto give an oil which
- customwas triturated with ethyl ether
出典と根拠
- ORDレコード
- ord-49d8304cdbec4ea2a75f2c2f5b3084f4
- 出典データセット
- uspto-grants-2003_08
- 特許番号
- US06610731B2
反応ノート
読み込み中…