Triethylamine → HCID 23000170、化合物

HRID 398366ノート

反応式

HRID 398366 の反応式
[CH:1]1([CH2:4][CH2:5][CH2:6][CH2:7][OH:8])[CH2:3][CH2:2]1.C(N(CC)CC)C.[CH3:16][S:17](Cl)(=[O:19])=[O:18]>C(Cl)Cl>[CH3:16][S:17]([O:8][CH2:7][CH2:6][CH2:5][CH2:4][CH:1]1[CH2:3][CH2:2]1)(=[O:19])=[O:18]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 230002214-Cyclopropylbutan-1-ol

生成物 1

HCID 23000170HCID 23000170、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a stirred 0° C. solution of 683 mg (6.0 mmol) of 4-cyclopropylbutanol and 1.25 mL (9.0 mmol) of triethylamine in 10 mL of CH2Cl2 was added 697 μL (9.0 mmol) of methanesulfonyl chloride dropwise under Ar. The cold bath was allowed to expire over a 2 h period at which time the reaction mixture was diluted with CH2Cl2, washed with cold 1M HCl, water, sat. NaHCO3, brine, dried over MgSO4 and the solvents removed to give the title compound as a yellow oil:

後処理

  1. washwashed with cold 1M HCl, water, sat. NaHCO3, brine
  2. dry with materialdried over MgSO4
  3. customthe solvents removed

出典と根拠

ORDレコード
ord-ffeb22255aad496b8c70f40a043f0a49
出典データセット
uspto-grants-2003_08
特許番号
US06610692B1

反応ノート

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