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Methanesulfonic Acid → Cholesta-1,5,7-trien-3-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanesulfonic Acid | HCID 6395 | — |
| 反応物 | Isopropenyl acetate | HCID 7916 | — |
| 反応物 | 1,4,6-Cholestatrien-3-one | HCID 107390 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Cholesta-1,5,7-trien-3-ol | HCID 18611553 | 61.2% |
反応手順
To a mixture of 19 g (0.05 mol) of cholesta-1,4,6-trien-3-one (I), 4.8 g (0.05 mol) of methanesulfonic acid and 200 g (2 mol) of isopropenyl acetate were added 200 ml of toluene, and the resulting mixture was then heated under reflux for 6 hours. After completion of the reaction, the same treatment as in Example 1 was carried out to yield 11.7 g of cholesta-1,5,7-trien-3-ol (IV). The yield was 61%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04723045 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-d91476894bba4ff4b3f1ab9b2aac825a |
| 出典メモ | uspto-grants-1988_02 |