関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | 3-Fluoro-4-hydroxybenzeneacetic acid | HCID 68014 | — |
| 生成物 | Methyl 2-(3-fluoro-4-hydroxyphenyl)acetate | HCID 10797559 | 97.6% |
反応手順
A solution of (3-fluoro-4-hydroxy-phenyl)-acetic acid (1.0 g, 5.87 mmol) in methanol (20 mL) was treated with a catalytic amount of sulfuric acid. The reaction was heated at 120° C. for 6 h. At this time, the reaction was concentrated in vacuo. Flash chromatography (Merck Silica gel 60, 230-400 mesh, 50/50 hexanes/ethyl acetate) afforded (3-fluoro-4-hydroxy-phenyl)-acetic acid methyl ester (1.05 g, 97.6%) as a white solid: mp 34-36° C.: EI-HRMS m/e calcd for C9H9FO3 (M+) 184.0535, found 184.0533.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06610846B1 |
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| 出典データセット | uspto-grants-2003_08 |
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| ORD ID | ord-dc28b82ec0634ae9918a4b6be6f07d5e |
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| 出典メモ | uspto-grants-2003_08 |
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