関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methyl morpholine oxide | HCID 82029 | — |
| 反応物 | 2-t-Butyldiphenylsilyloxymethyl-2-propene-1-ol | HCID 11450232 | — |
| 触媒 | HCID 178419074 | HCID 178419074 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-t-Butyldiphenylsilyloxymethyl-2-propenal | HCID 53309787 | 83% |
反応手順
A mixture of 2-t-butyldiphenylsilyloxymethyl-2-propene-1-ol (25.5 g, 86.7 mmol), molecular sieves in powder (26 g), N-methylmorpholine-N-oxide (15.3 g, 130 mmol) and tetrapropylammoniumperruthenate (1.5 g, 4 mmol) in anhydrous dichloromethane (400 ml) is stirred overnight at 20° C. Then the reaction mixture is concentrated in vacuo and purified by flash chromatography on silica gel to give the title product (21 g, 83%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05817647 |
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| 出典データセット | uspto-grants-1998_10 |
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| ORD ID | ord-8661d624be634f08924ce746aaf0c6dc |
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| 出典メモ | uspto-grants-1998_10 |
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