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Diethyl Carbonate → 4-Ethyl-4-hydroxymethyl-2-oxazolidinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Carbonate | HCID 7766 | — |
| 反応物 | 2-Amino-2-ethyl-1,3-propanediol | HCID 8282 | — |
| 触媒 | Sodium Methoxide | HCID 10942334 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-Ethyl-4-hydroxymethyl-2-oxazolidinone | HCID 11263559 | 66.5% |
反応手順
Sodium methoxide (2.2 g, Aldrich) was added to a solution of 2-amino-2-ethyl-1,3-propanediol(100.0 g, Aldrich) and diethyl carbonate (169.0 g, Aldrich) This solution was refluxed in a Dean Stark apparatus until no more EtOH was collected. The reaction mixture was cooled, added acetone(200 ml) and allowed to stand overnite at room temperature. The resulting suspension was filtered to give 81.0 g of the desired product as a beige solid. 1H NMR consistent with the proposed structure.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05817652 |
| 出典データセット | uspto-grants-1998_10 |
| ORD ID | ord-58e4b581318740f5b42cfeb857ddca99 |
| 出典メモ | uspto-grants-1998_10 |