Sodium Bicarbonate → HCID 11117620、化合物

反応式

C([NH:7][C:8]1[C:13]([C:14](O)([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH2:15][C:16](OC(C)(C)C)=[O:17])=[CH:12][CH:11]=[CH:10][N:9]=1)(=O)C(C)(C)C.C(=O)(O)[O-].[Na+]>Cl.O1CCOCC1>[C:23]1([C:14]2[C:13]3[C:8](=[N:9][CH:10]=[CH:11][CH:12]=3)[NH:7][C:16](=[O:17])[CH:15]=2)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

参加物

実験手順

Tert-butyl 2-pivaloylamino-β-hydroxy-β-phenyl-3-pyridinepropanoate (2.09 g, 5.25 mmol) was dissolved in a mixed solvent of 3N hydrochloric acid aqueous solution (10 ml) and dioxane (10 ml), and the solution was heated under reflux for 3 days. After cooling to room temperature, saturated sodium bicarbonate aqueous solution was added for neutralization. The reaction mixture was filtered, and the resulting crystals were thoroughly washed with water and recrystallized from acetonitrile to give 4-phenyl-1,8-naphthyridin-2(1H)-one (600 mg, 51%).