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2,4,5-Trifluorobenzoyl chloride → 5-(N-[2,4,5-trifluorobenzoyl]amino)-3-(1-methylpiperidin-4-yl)pyrrolo[3,2-b]pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,4,5-Trifluorobenzoyl chloride | HCID 145164 | — |
| 反応物 | 3-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-ylamine | HCID 10220230 | — |
| 生成物 | 5-(N-[2,4,5-trifluorobenzoyl]amino)-3-(1-methylpiperidin-4-yl)pyrrolo[3,2-b]pyridine | HCID 19601459 | 87.8% |
反応手順
Beginning with 0.010 gm (0.044 mMol) 5-amino-3-(1-methylpiperidin-4-yl)pyrrolo[3,2-b]pyridine and 0.007 mL (0.055 mMol) 2,4,5-trifluorobenzoyl chloride, 0.015 gm (86%) of the title compound were prepared essentially by the procedure described in Example 7.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05817671 |
| 出典データセット | uspto-grants-1998_10 |
| ORD ID | ord-b4db58934a2d43fab114d1eed35b3c00 |
| 出典メモ | uspto-grants-1998_10 |