関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sulfanilamide | HCID 5333 | — |
| 反応物 | 2-Chloro-4-methoxypyridine | HCID 1991128 | — |
| 試薬 | Cesium carbonate | HCID 10796 | — |
| 触媒 | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| 触媒 | Palladium (II) acetate | HCID 4144353 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | 4-[(4-Methoxy-2-pyridinyl)amino]benzenesulfonamide | HCID 101787706 | 0% |
反応手順
A mixture of 4-aminobenzenesulfonamide (190mg, 1.10 mmol), 2-chloro-4-methoxypyridine (135 mg, 0.94 mmol), diacetoxypalladium (13mg, 0.06 mmol), cesium carbonate (417mg, 1.28 mmol) and (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (50 mg, 0.09 mmol) in NMP (2.0 mL) was heated **in the microwave** for 10 min at 150 °C. LC MS crude mix. FLA-04227-80-01 showed no reaction. Another 30 min at 150°C in the microwave provided FLA-04227-80-02 (crude mix.). No product. **Discard.**
情報源と証拠
| 出典データセット | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-370d0a5fbe29487785ea2b57f66774a2 |
|---|
| 出典メモ | 750 AstraZeneca ELN dataset |
|---|
