Methyl chloroacetate → HCID 18969559、化合物

HRID 399017

反応式

HRID 399017 の反応式
[OH:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][CH:3]=1.Cl[CH2:12][C:13]([O:15][CH3:16])=[O:14].C(=O)([O-])[O-].[K+].[K+]>[I-].[K+].CC(C)=O>[CH3:16][O:15][C:13]([CH2:12][O:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][CH:3]=1)=[O:14]

参加物

6

反応物 3

HCID 7295Methyl chloroacetateHCID 11430Potassium CarbonateHCID 5245086-Hydroxyindole

生成物 1

HCID 18969559HCID 18969559、化合物収率 63.3%

試薬・触媒・溶媒 2

HCID 4875Potassium Iodide触媒HCID 180Acetone溶媒

実験手順

6-Hydroxyindole (2.9 g), methyl chloroacetate (2.7 g), potassium carbonate (5.5 g) and potassium iodide (0.2 g) are added to acetone (100 ml), and the mixture is refluxed for 8 hours. The reaction mixture is cooled to room temperature, and the insoluble materials are removed by filtration. The filtrate is evaporated under reduced pressure. The residue is purified by silica gel column chromatography (eluent; chloroform) to give 6-methoxycarbonylmethoxyindole (2.83 g).

後処理

  1. temperaturethe mixture is refluxed for 8 hours
  2. customthe insoluble materials are removed by filtration
  3. customThe filtrate is evaporated under reduced pressure
  4. customThe residue is purified by silica gel column chromatography (eluent; chloroform)

出典と根拠

ORDレコード
ord-59f19f98a90542538f9d78d9b52ab590
出典データセット
uspto-grants-1998_10
特許番号
US05817689

関連ノート

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