Water → 2-(p-Chlorophenyl)-4-[(3,4-dichlorophenyl)sulfonyl]-5-(trifluoromethyl)pyrrole-3-carbonitrile

HRID 399036ノート

反応式

HRID 399036 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10]([C:24]([F:27])([F:26])[F:25])=[C:11]([S:15][C:16]3[CH:21]=[CH:20][C:19]([Cl:22])=[C:18]([Cl:23])[CH:17]=3)[C:12]=2[C:13]#[N:14])=[CH:4][CH:3]=1.S([O-])(O[O-])(=O)=[O:29].[K+].[K+].[OH2:36]>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10]([C:24]([F:26])([F:27])[F:25])=[C:11]([S:15]([C:16]3[CH:21]=[CH:20][C:19]([Cl:22])=[C:18]([Cl:23])[CH:17]=3)(=[O:29])=[O:36])[C:12]=2[C:13]#[N:14])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 962Water2 回HCID 10313463Potassium peroxymonosulphate2 回HCID 189695992-(p-Chlorophenyl)-4-[(3,4-dichlorophenyl)thio]-5-(trifluoromethyl)pyrrole-3-carbonitrile

生成物 1

HCID 189696052-(p-Chlorophenyl)-4-[(3,4-dichlorophenyl)sulfonyl]-5-(trifluoromethyl)pyrrole-3-carbonitrile

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

反応条件

温度
25 °C

実験手順

A solution of 2-(p-chlorophenyl)-4-[(3,4-dichlorophenyl)thio]-5-(trifluoromethyl)pyrrole-3-carbonitrile (1.0 g, 2.2 mmol) in methanol is treated with a solution of potassium peroxymonosulfate (2.95 g) in water (7.4 mL), stirred at 25° C. for 24 hours, diluted with additional methanol, treated with a solution of potassium peroxymonosulfate (2.7 g) in water (7.6 mL), stirred at 25° C. for 24 hours, and filtered to obtain a solid which is washed with water and dried to give the title product a white solid (mp >225° C.).

後処理

  1. stirringstirred at 25° C. for 24 hours
  2. filtrationfiltered
  3. customto obtain a solid which
  4. washis washed with water
  5. customdried

出典と根拠

ORDレコード
ord-807fd2ef2d954439b65599f2a034137a
出典データセット
uspto-grants-1998_10
特許番号
US05817691

反応ノート

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