化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Hydroxide → 1,3,3-Trichloro-2-methyl-7-oxabicyclo[4.1.0]heptane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 1-Methyl-2,2,6,6-tetrachlorocyclohexanol | HCID 18970952 | — |
| 反応物 | 1,3-Dichloro-3-fluoro-7-oxabicyclo[4.1.0]heptane | HCID 18970966 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1,3,3-Trichloro-2-methyl-7-oxabicyclo[4.1.0]heptane | HCID 18970971 | 95.5% |
反応手順
The same procedure was employed as for the preparation of 2e in Example 17: it was performed with 3.97 g (15.75 mmol) of crude alcohol 1j, 20 cm3 of distilled water and 2.4 g (60 mmol) of sodium hydroxide; reaction time was 1 h 15 min; ether extraction (5×40 cm3); 3.29 g of epoxide 2h were obtained having a 95.5% yield based on the ketone (macrobore GC purity>99%)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05817890 |
| 出典データセット | uspto-grants-1998_10 |
| ORD ID | ord-fa28d522f0fe44109c518a5623e6ed9b |
| 出典メモ | uspto-grants-1998_10 |