化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 3-Chloro-o-cresol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 1,3,3-Trichloro-2-methyl-7-oxabicyclo[4.1.0]heptane | HCID 18970971 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-Chloro-o-cresol | HCID 14856 | 89.2% |
反応手順
2 g (9.28 mmol) of epoxide 2h in solution in 5 cm3 of anhydrous DMF were heated to reflux for 3 h. The solution was acidified (pH=1) with 3N HCl, extracted with ether (4×25 cm3), dried over MgSO4, filtered and evaporated down. The crude product obtained was purified by flash chromatography on silica (eluent: ether/petroleum ether=5/95). 1.18 g of phenol 4e were obtained (macrobore GC purity>96%). The yield of compound 4e was 89%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05817890 |
| 出典データセット | uspto-grants-1998_10 |
| ORD ID | ord-82f33f72dd9547d68c3b69b304db87fc |
| 出典メモ | uspto-grants-1998_10 |