Methyl Bromide → 2-Bromo-6-ethoxynaphthalene

HRID 399359

反応式

HRID 399359 の反応式
Br[CH3:2].[Br:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[CH:10]=[C:9](O)[CH:8]=[CH:7]2.[C:15](=[O:18])([O-])[O-].[K+].[K+]>CC(C)=O>[Br:3][C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:18][CH2:15][CH3:2])[CH:10]=2)[CH:5]=1

参加物

5

反応物 3

HCID 6323Methyl BromideHCID 11430Potassium CarbonateHCID 271446-Bromo-2-naphthalenol

生成物 1

HCID 2368582-Bromo-6-ethoxynaphthalene

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

This experimental procedure is an O-alkylation. A solution of bromomethane (48.90 g, 0.45 mol) is added dropwise to a stirred refluxing mixture of 6-Bromo-2-naphthol (40.00 g, 0.18 mol) and potassium carbonate (63.00 g, 0.46 mol) in acetone. The stirred mixture is heated under reflux for 24 hours (ie until glc analysis reveals a complete reaction). The potassium carbonate is filtered off, water is added to filtrate and the product is recrystallised from ethanol to give a yield of 43.92 g (97%).

後処理

  1. temperaturerefluxing
  2. temperatureThe stirred mixture is heated
  3. temperatureunder reflux for 24 hours (ie until glc analysis
  4. customa complete reaction)
  5. filtrationThe potassium carbonate is filtered off
  6. additionwater is added to filtrate
  7. customthe product is recrystallised from ethanol
  8. customto give a yield of 43.92 g (97%)

出典と根拠

ORDレコード
ord-a2e80eb80d1047d1a23f28aea9355410
出典データセット
uspto-grants-1998_10
特許番号
US05820781

関連ノート

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