HCID 10604239、化合物 → L 738167
反応式
[C:1]1([CH3:45])[CH:6]=[CH:5][C:4]([S:7]([NH:10][C@@H:11]([CH2:15][NH:16][C:17]([C:19]2[CH:44]=[C:22]3[C:23](=[O:43])[N:24]([CH2:28][CH2:29][CH:30]4[CH2:35][CH2:34][N:33](C(OC(C)(C)C)=O)[CH2:32][CH2:31]4)[CH2:25][CH2:26][CH2:27][N:21]3[N:20]=2)=[O:18])[C:12]([OH:14])=[O:13])(=[O:9])=[O:8])=[CH:3][CH:2]=1>C(Cl)Cl>[C:1]1([CH3:45])[CH:6]=[CH:5][C:4]([S:7]([NH:10][C@@H:11]([CH2:15][NH:16][C:17]([C:19]2[CH:44]=[C:22]3[C:23](=[O:43])[N:24]([CH2:28][CH2:29][CH:30]4[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]4)[CH2:25][CH2:26][CH2:27][N:21]3[N:20]=2)=[O:18])[C:12]([OH:14])=[O:13])(=[O:8])=[O:9])=[CH:3][CH:2]=1参加物
3
試薬・触媒・溶媒 1
実験手順
15-1 (7.42 g, 11.48 mmol) was placed in a 1L round bottom flask equipped with a magnetic stir bar. Methylene chloride was added and the reaction mixture was cooled to 0°-5°. Hydrogen chloride was bubbled through the suspension with stirring. After about 2 min. the solid went into solution, and soon afterward a second precipitate formed. After bubbling gas through the suspension for an additional 5 min. the reaction flask was warmed to room temperature. After 30 min. the contents of the reaction flask were concentrated. The resulting white solid was the hydrochloride salt of 15-2 and by HPLC analysis was of >99% purity.
後処理
- customequipped with a magnetic stir bar
- temperature