4-Chloro-6,7-dimethoxyquinazoline hydrochloride → 6,7-Dimethoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline dihydrochloride salt

HRID 399465

反応式

HRID 399465 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][O:8][C:9]1[C:10]([CH3:16])=[CH:11][C:12]([NH2:15])=[CH:13][CH:14]=1.[ClH:17].[Cl:18][C:19]1[C:28]2[C:23](=[CH:24][C:25]([O:31][CH3:32])=[C:26]([O:29][CH3:30])[CH:27]=2)[N:22]=[CH:21][N:20]=1>>[ClH:18].[ClH:17].[CH3:30][O:29][C:26]1[CH:27]=[C:28]2[C:23](=[CH:24][C:25]=1[O:31][CH3:32])[N:22]=[CH:21][N:20]=[C:19]2[NH:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)=[C:10]([CH3:16])[CH:11]=1

参加物

3

反応物 2

HCID 220221614-Chloro-6,7-dimethoxyquinazoline hydrochlorideHCID 234382883-Methyl-4-(pyridin-2-ylmethoxy)aniline

生成物 1

HCID 189676336,7-Dimethoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline dihydrochloride salt収率 60%

実験手順

Using an analogous procedure to that described in Example 1, 5-amino-2-tolyl 2-pyridylmethyl ether was reacted with 4-chloro-6,7-dimethoxyquinazoline hydrochloride to give 6,7-dimethoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline dihydrochloride salt in 60% yield, m.p. 239°-241° C.;

出典と根拠

ORDレコード
ord-f8567c0c0aa34bd9a8d0375068c3889a
出典データセット
uspto-grants-1998_10
特許番号
US05821246

関連ノート

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