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Methanol → Methyl 4-methoxypyridine-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Methyl 4-Chloropicolinate | HCID 820890 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 生成物 | Methyl 4-methoxypyridine-2-carboxylate | HCID 1519345 | — |
反応手順
A mixture of methyl 4-chloropyridine-2-carboxylate (3.7 g), sodium metal (0.5 g) and methanol (100 ml) was stirred and heated to reflux for 8 hours. The mixture was evaporated and the residue was partitioned between ethyl acetate and water. The organic phase was dried (MgSO4) and evaporated to give methyl 4-methoxypyridine-2-carboxylate (3 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05821246 |
| 出典データセット | uspto-grants-1998_10 |
| ORD ID | ord-20b68bca3eea4b289fb28d8fe1e448c8 |
| 出典メモ | uspto-grants-1998_10 |