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4-Chloro-7-methoxyquinazolin-6-yl acetate--hydrogen chloride (1/1) → 6-Acetoxy-7-methoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chloro-7-methoxyquinazolin-6-yl acetate--hydrogen chloride (1/1) | HCID 22022159 | — |
| 反応物 | 3-Methyl-4-(pyridin-2-ylmethoxy)aniline | HCID 23438288 | — |
| 生成物 | 6-Acetoxy-7-methoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline | HCID 18967644 | 60% |
反応手順
Using an analogous procedure to that described in Example 1, 6-acetoxy-4-chloro-7-methoxyquinazoline, hydrochloride salt, was reacted with 5-amino-2-tolyl 2-pyridylmethyl ether to give 6-acetoxy-7-methoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline in 60% yield;
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05821246 |
| 出典データセット | uspto-grants-1998_10 |
| ORD ID | ord-b3526fe5e063495b896cd4af83ece54b |
| 出典メモ | uspto-grants-1998_10 |