化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → HCID 178508933、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 2-((Acetyloxy)methoxy)ethyl acetate | HCID 100999 | — |
| 反応物 | Diacetylguanine | HCID 136360183 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | HCID 178508933 | HCID 178508933 | — |
反応手順
Matsumoto in Chem Pharm Bull, 36(3), 1153-1157 and JP 63-107982 teaches a process for the synthesis of acyclovir(Ia) by condensation of diacetyl guanine (DAG Va) with 2-oxa-1,4-butanediol diacetate (OBDDA, VIIa) in DMSO in presence of an acid catalyst to get a mixture of N-9/N-7 isomer (66:26). The former is isolated by column chromatography and deacetylated with methanolic ammonia to give acyclovir. Overall yield of acyclovir from guanine is 42%
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05821367 |
| 出典データセット | uspto-grants-1998_10 |
| ORD ID | ord-5825b520528642f6bbfe1b0fcb252da6 |
| 出典メモ | uspto-grants-1998_10 |