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Acetic Anhydride → 1-Benzyl-3-(3-chlorophenyl)-1-(cyanoacetyl)urea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | Cyanoacetic acid | HCID 9740 | — |
| 反応物 | 1-Benzyl-3-(3-chlorophenyl)urea | HCID 581390 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 1-Benzyl-3-(3-chlorophenyl)-1-(cyanoacetyl)urea | HCID 2822854 | — |
反応手順
A mixture of 1-benzyl-3-(3-chlorophenyl)urea (44.78 g) and cyanoacetic acid (16.11 g) was ground together and then acetic anhydride (48 ml) added. The resulting mixture was heated and stirred at 75°-80° C. for 16 h. It was then allowed to cool, diluted with ether and the product filtered off and washed with ether. This was then recrystallised from toluene with a hot filtration. Yield=20.15 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05821366 |
| 出典データセット | uspto-grants-1998_10 |
| ORD ID | ord-14d924b3ea464728bb4f78179e52d8d6 |
| 出典メモ | uspto-grants-1998_10 |