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Triethylamine → 3-(3-Chloro-2-methylphenyl)-1-methyl-2-thioxo-imidazolidin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1-Chloro-3-isothiocyanato-2-methylbenzene | HCID 140504 | — |
| 反応物 | Ethyl N-methylaminoacetate hydrochloride | HCID 171173 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 3-(3-Chloro-2-methylphenyl)-1-methyl-2-thioxo-imidazolidin-4-one | HCID 18968212 | 83.3% |
反応手順
The title compound was prepared by the procedure described in Example 1 using 13.2 g of 3-chloro-2-methylphenyl-isothiocyanate, 11.0 g of sarcosine ethyl ester hydrochloride, 25 g of triethyl amine, and 300 mL of chloroform. Crystallization from diethyl ether afforded the title compound (15.2 g) as a tan solid, m.p. 122°-124° C. Anal. Calcd. for C11H11Cl N2O S: C, 51.87; H, 4.35; N,11.00. Found: C, 51.96; H, 4.21; N, 11.05. Mass spectrum (EI, M.+) m/z 254/256.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05821372 |
| 出典データセット | uspto-grants-1998_10 |
| ORD ID | ord-58317836117e413f82d1d06fa2f3cd8b |
| 出典メモ | uspto-grants-1998_10 |