化工社化工社 化学情報印刷レポート · 研究参考用
(+-)-Pantolactone → Keto-pantoyllactone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (+-)-Pantolactone | HCID 989 | — |
| 反応物 | Trichloroisocyanuric Acid | HCID 6909 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 触媒 | Tempo | HCID 2724126 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Keto-pantoyllactone | HCID 39 | 89.4% |
反応手順
2.5 g (19.2 mmol) of pantolactone were reacted with 1.8 g (7.7 mmol) of trichloroisocyanuric acid in the presence of 30 mg (0.12 mmol) of TEMPO derivative C and 1.65g (20.1 mmol) of sodium acetate analogously to Example 14. In contrast to Example 14, ethyl acetate (20 ml) was used as the solvent. The reaction had finished after 2 hours. After recrystallization of the crude product there were obtained 2.2 g (89%) of ketopantolactone, m.p. 68°-69° C., GC content: 100% (area percent).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05821374 |
| 出典データセット | uspto-grants-1998_10 |
| ORD ID | ord-eabf6f8f96b0446daa31797acac3cb72 |
| 出典メモ | uspto-grants-1998_10 |