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Hydrochloric Acid → 1-Propanone, 3-(dimethylamino)-1-phenyl-, hydrochloride (1:1)
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | Acetophenone | HCID 7410 | — |
| 反応物 | Dimethylamine, hydrochloride | HCID 10473 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-Propanone, 3-(dimethylamino)-1-phenyl-, hydrochloride (1:1) | HCID 92844 | — |
反応手順
Acetophenone (29.1 ml, 0.25 mol), para-formaldehyde (12.0 g, 0.40 mol) and dimethyl amine hydrochloride (28.5 g, 0.35 mol) are suspended in ethanol (50 ml). Concentrated hydrochloric acid (0.5 ml) is added and the mixture is heated to reflux for 4 h. Then acetone (200 ml) is added and the resulting clear solution is allowed to cool to ambient temperature. The precipitate is collected by filtration and crystallized from ethanol yielding the title compound (40.7 g, 76.0% of theoretical yield) as colorless crystals with mp. 158° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05824624 |
| 出典データセット | uspto-grants-1998_10 |
| ORD ID | ord-ab050129ebc54d3b8ce218ab6033913d |
| 出典メモ | uspto-grants-1998_10 |