Dimethylformamide → Methyl 3-(2-carbamoylpyrrol-1-yl)benzoate

HRID 399819ノート

反応式

HRID 399819 の反応式
[NH4+].[OH-].ClC(Cl)(Cl)[C:5]([C:7]1[N:8]([C:12]2[CH:13]=[C:14]([CH:19]=[CH:20][CH:21]=2)[C:15]([O:17][CH3:18])=[O:16])[CH:9]=[CH:10][CH:11]=1)=[O:6].C[N:25](C)C=O.C(OCC)(=O)C>O>[C:5]([C:7]1[N:8]([C:12]2[CH:13]=[C:14]([CH:19]=[CH:20][CH:21]=2)[C:15]([O:17][CH3:18])=[O:16])[CH:9]=[CH:10][CH:11]=1)(=[O:6])[NH2:25]

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 14923Ammonium HydroxideHCID 18945198Methyl 3-(2-trichloroacetylpyrrol-1-yl)benzoate

生成物 1

HCID 18945445Methyl 3-(2-carbamoylpyrrol-1-yl)benzoate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

28% Ammonia aqueous solution (0.4 ml) was added to a mixture of methyl 3-(2-trichloroacetylpyrrol-1-yl)benzoate (1.0 g) and N,N-dimethylformamide (2 ml), and the mixture was stirred for 1.5 hours at ambient temperature. The mixture was poured into a mixture of ethyl acetate and water. The separated organic layer was washed with water, dried over magnesium sulfate and evaporated in vacuo. The residue was triturated with diisopropyl ether to give methyl 3-(2-carbamoylpyrrol-1-yl)benzoate (0.61 g).

後処理

  1. washThe separated organic layer was washed with water
  2. dry with materialdried over magnesium sulfate
  3. customevaporated in vacuo
  4. customThe residue was triturated with diisopropyl ether

出典と根拠

ORDレコード
ord-c7cb23aa2e8f47fd8db795ff3d1f02f4
出典データセット
uspto-grants-1998_10
特許番号
US05824691

反応ノート

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