Methanol → 2-[3-(2-Cyanopyrrol-1-yl) benzoyl]guanidine hemisulfate

HRID 399871ノート

反応式

HRID 399871 の反応式
[S:1](=[O:5])(=[O:4])([OH:3])[OH:2].[C:6]([C:8]1[N:9]([C:13]2[CH:14]=[C:15]([CH:22]=[CH:23][CH:24]=2)[C:16]([N:18]=[C:19]([NH2:21])[NH2:20])=[O:17])[CH:10]=[CH:11][CH:12]=1)#[N:7].CO>C(OCC)(=O)C>[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[C:6]([C:8]1[N:9]([C:13]2[CH:14]=[C:15]([CH:22]=[CH:23][CH:24]=2)[C:16]([N:18]=[C:19]([NH2:20])[NH2:21])=[O:17])[CH:10]=[CH:11][CH:12]=1)#[N:7].[C:6]([C:8]1[N:9]([C:13]2[CH:14]=[C:15]([CH:22]=[CH:23][CH:24]=2)[C:16]([N:18]=[C:19]([NH2:20])[NH2:21])=[O:17])[CH:10]=[CH:11][CH:12]=1)#[N:7]

参加物

5

反応物 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 189451892-[3-(2-Cyanopyrrol-1-yl)benzoyl]guanidine

生成物 1

HCID 1317208902-[3-(2-Cyanopyrrol-1-yl) benzoyl]guanidine hemisulfate

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Conc. sulfuric acid (0.42 ml) was added to a mixture of 2-[3-(2-cyanopyrrol-1-yl)benzoyl]guanidine (2.0 g) and methanol (20 ml), and the mixture was stirred for 30 minutes at ambient temperature. To the mixture was added ethyl acetate (20 ml), and the isolated precipitate was collected by filtration. The precipitate was recrystallized from methanol-water to give 2-[3-(2-cyanopyrrol-1-yl) benzoyl]guanidine hemisulfate (1.53 g).

後処理

  1. filtrationthe isolated precipitate was collected by filtration
  2. customThe precipitate was recrystallized from methanol-water

出典と根拠

ORDレコード
ord-97023756ec204dcb8260329331a5d280
出典データセット
uspto-grants-1998_10
特許番号
US05824691

反応ノート

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