Methanesulfonic Acid → 2-[3-(2-Cyanopyrrol-1-yl)benzoyl]guanidine methanesulfonate

HRID 399878ノート

反応式

HRID 399878 の反応式
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[C:6]([C:8]1[N:9]([C:13]2[CH:14]=[C:15]([CH:22]=[CH:23][CH:24]=2)[C:16]([N:18]=[C:19]([NH2:21])[NH2:20])=[O:17])[CH:10]=[CH:11][CH:12]=1)#[N:7].C(OCC)(=O)C>CO>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[C:6]([C:8]1[N:9]([C:13]2[CH:14]=[C:15]([CH:22]=[CH:23][CH:24]=2)[C:16]([N:18]=[C:19]([NH2:20])[NH2:21])=[O:17])[CH:10]=[CH:11][CH:12]=1)#[N:7]

参加物

5

反応物 3

HCID 6395Methanesulfonic AcidHCID 8857Ethyl AcetateHCID 189451892-[3-(2-Cyanopyrrol-1-yl)benzoyl]guanidine

生成物 1

HCID 867532352-[3-(2-Cyanopyrrol-1-yl)benzoyl]guanidine methanesulfonate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methanesulfonic acid (0.8 ml) was added to a mixture of 2-[3-(2-cyanopyrrol-1-yl)benzoyl]guanidine (2.0 g) in methanol (20 ml) and the mixture was stirred for 30 minutes at ambient temperature. To the mixture was added ethyl acetate (20 ml) and isolated precipitate was collected by filtration. The precipitate was recrystallized from water to give 2-[3-(2-cyanopyrrol-1-yl)benzoyl]guanidine methanesulfonate (1.48 g).

後処理

  1. customisolated precipitate
  2. filtrationwas collected by filtration
  3. customThe precipitate was recrystallized from water

出典と根拠

ORDレコード
ord-4f19722ec46d44dcba0ab3ec1beba662
出典データセット
uspto-grants-1998_10
特許番号
US05824691

反応ノート

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