関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | 3,4,5-Trimethoxyphenylacetic acid | HCID 70372 | — |
| 触媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-(3,4,5-trimethoxyphenyl)acetyl Chloride | HCID 11032124 | — |
反応手順
Combine 3,4,5-trimethoxy-phenyl-acetic acid (2.26 g, 10 mmol) and dichloromethane (50 mL). Cool to -5° C. using a ice-salt bath. Add 2 drops of dimethylformamide followed by dropwise addition of oxalyl chloride (1.74 mL, 20 mmol). after 1 hour, warm the reaction mixture to ambient temperature. After 2 hours, evaporate the reaction mixture in vacuo to give the title compound as a liquid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05824690 |
|---|
| 出典データセット | uspto-grants-1998_10 |
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| ORD ID | ord-1a265be0a8704ec68c71929a1a4730bb |
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| 出典メモ | uspto-grants-1998_10 |
|---|
