1-Propanesulfonate → 1-[2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl]-4-phenyl-piperidine-4-carboxylic acid 4-methylpiperazine-amide hydrochloride

関与物質

役割	名称	HCID	仕込み量
反応物	1-Propanesulfonate	HCID 4431756	—
反応物	Ethyl acetate hexane	HCID 21226206	—
反応物	4-Phenyl-piperidine-4-carboxylic acid 4-methylpiperazine-amide hydrochloride	HCID 67562154	—
反応物	2-[1-(3,4,5-Trimethoxy-benzoyl)-3-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate	HCID 86750906	—
溶媒	Dichloromethane methanol	HCID 21226129	—
生成物	1-[2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl]-4-phenyl-piperidine-4-carboxylic acid 4-methylpiperazine-amide hydrochloride	HCID 67562211	—

反応手順

Prepare by the method of example 27.3.1 using 2-[3-(3,4-dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate (2.8 g, 5.24 mmol) and 4-phenyl-piperidine-4-carboxylic acid 4-methylpiperazine-amide pyrrolidin-3-yl]-ethyl-methanesulfonate (2.8 g, 5.24 mmol) and 4-phenyl-piperidine-4-carboxylic acid 4-methylpiperazine-amide hydrochloride (2.8 g, 3.9 mmol). Chromatograph on silica gel eluting sequentially with 50% ethyl acetate/hexane, 3% methanol/dichloromethane, and then 6% methanol/dichloromethane to give the title compound.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US05824690
出典データセット	uspto-grants-1998_10
ORD ID	ord-c8a52108f6f846b09832c344e0562d86
出典メモ	uspto-grants-1998_10