関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 3,4-Dimethylpyridine | HCID 11417 | — |
| 反応物 | Selenium Dioxide | HCID 24007 | — |
| 溶媒 | Diphenyl Ether | HCID 7583 | — |
| 生成物 | 3-Methyl-isonicotinic acid | HCID 1502003 | 44% |
反応手順
To a hot (155° C.) solution of 10.7 g (0.1 mol) of 3,4-lutidine in 100 mL diphenylether, was added 18 g (0.16 mol) selenium dioxide in portions. After about 20 minutes, the reaction was heated to 185° C. and allowed to react for approximately thirty minutes. After cooling, the reaction mixture was diluted with water and filtered. The filtrate was extracted with chloroform and the chloroform extracts were then concentrated under reduced pressure to provide 6.0 g of a pale brown solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05827858 |
|---|
| 出典データセット | uspto-grants-1998_10 |
|---|
| ORD ID | ord-879e9ee078d24867a087172f9db13fe0 |
|---|
| 出典メモ | uspto-grants-1998_10 |
|---|
