Benzyl Bromide → Benzenemethanamine, N-hexyl-

反応式

[CH2:1]([NH2:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[CH2:8](Br)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[CH2:8]([NH:7][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH3:6])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

参加物

反応物 2

HCID 7498Benzyl Bromide

HCID 8102Hexylamine

生成物 1

HCID 485395Benzenemethanamine, N-hexyl-収率 89%

実験手順

A! 200 ml (1.49 moles) of hexylamine cooled to 5° C. were added with benzyl bromide (42.3 ml, 0.35 mole), and the resultant mixture was stirred for 1 hour at room temperature. The hexylamine in excess was then distilled off under vacuum, and the residue dissolved in 300 ml of ethyl ether and washed with 200 ml of 0.5N sodium hydroxide. The ether phase was anhydrified over sodium sulfate and evaporated to dryness thus yielding 75.5 g of a crude which, by distillation under vacuum, gave 59 g (yield: 89%) of N-benzyl-N-hexylamine (b.p.--90°-95° C./0.6 mmHg).

後処理

distillationThe hexylamine in excess was then distilled off under vacuum
dissolutionthe residue dissolved in 300 ml of ethyl ether
washwashed with 200 ml of 0.5N sodium hydroxide
customevaporated to dryness
customthus yielding 75.5 g of a crude which
distillationby distillation under vacuum

出典と根拠

ORDレコード: ord-b52e3838c7d1473386d8e76d81f29a25
出典データセット: uspto-grants-1998_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05827881

反応ノート

読み込み中…

参加物