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Tetrahydrofuran → 2-Vinyl-6-methoxynaphthalene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | 6-Methoxynaphthalene-1-carbaldehyde | HCID 12843040 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 2-Vinyl-6-methoxynaphthalene | HCID 603535 | 90% |
反応手順
6-Methoxy-naphthaldehyde (432 mg, 2.35 mmol) is added to a solution of instantaneous ylide (Ph3P+Br−+NaNH2, 1.48 g, 2.4 mmol) in anhydrous THF (5 ml). After one hour of stirring at ambient temperature, it is diluted with ether, it is filtered on Celite, and it is chromatographed (hexane/AcOEt 5:1) to obtain 6-methoxy-2-vinyl-naphthalene (390 mg, 90%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08741593B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-26a379baa01243c797c0116c08dda5b4 |
| 出典メモ | uspto-grants-2014_06 |