Thiourea → 4,5,6,7-Tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-amine dihydrobromide
反応式
[NH2:1][C:2]([NH2:4])=[S:3].[BrH:5].[Br:6][CH:7]1[C:12](=O)[CH2:11][CH2:10][NH:9][CH2:8]1>C(O)C>[BrH:6].[BrH:5].[N:1]1[C:12]2[CH2:11][CH2:10][NH:9][CH2:8][C:7]=2[S:3][C:2]=1[NH2:4]参加物
4
実験手順
4.55 g thiourea was added to 15.2 g 3-Bromo-piperidin-4-one hydrobromide in 152 mL ethanol and refluxed for 20 h. The reaction was cooled and the solid was filtered, washed with ethanol and dried to give 15.8 g of the desired product.
後処理
- temperaturerefluxed for 20 h
- temperatureThe reaction was cooled
- filtrationthe solid was filtered
- washwashed with ethanol
- customdried
出典と根拠
- ORDレコード
- ord-68a607483a764d999179b43dd512532d
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08741892B2
反応ノート
読み込み中…