Methanol → Methyl 2-methylisonicotinate

HRID 400444

反応式

HRID 400444 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][N:10]=1)[C:5]([OH:7])=[O:6].[CH3:11]O>Cl>[CH3:11][O:6][C:5](=[O:7])[C:4]1[CH:8]=[CH:9][N:10]=[C:2]([CH3:1])[CH:3]=1

参加物

4

反応物 2

HCID 887MethanolHCID 27628212-Methylpyridine-4-carboxylic acid

生成物 1

HCID 11542811Methyl 2-methylisonicotinate

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

5 g 2-methyl-isonicotinic acid was stirred 24 h at 50° C. in 150 mL 1.3 mol/L HCl in methanol. The solvent was removed and water was added to the residue. The mixture was basified with saturated sodiumhydrogencarbonate solution and extracted with ethylacetate. The organic layer was dried with magnesiumsulfate and evaporated to give 4.5 g of the desired product.

後処理

  1. customThe solvent was removed
  2. additionwater was added to the residue
  3. extractionextracted with ethylacetate
  4. dry with materialThe organic layer was dried with magnesiumsulfate
  5. customevaporated

出典と根拠

ORDレコード
ord-2e0df64ed7db4a9abe1c7b7222727b7c
出典データセット
uspto-grants-2014_06
特許番号
US08741892B2

関連ノート

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