Potassium Carbonate → 3-(4-Fluoro-3-methyl-phenyl)-5-phenyl-pyrazol-1-yl-acetic acid methyl ester

HRID 400486ノート

反応式

HRID 400486 の反応式
F[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[NH:10][N:9]=2)=[CH:4][CH:3]=1.[C:20]([O-])([O-])=O.[K+].[K+].[CH3:26][O:27][C:28](=[O:31])[CH2:29]Br>CC(C)=O>[CH3:26][O:27][C:28](=[O:31])[CH2:29][N:9]1[C:8]([C:5]2[CH:6]=[CH:7][CH:2]=[CH:3][CH:4]=2)=[CH:12][C:11]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[C:15]([CH3:20])[CH:14]=2)=[N:10]1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 161054793,5-bis(4-fluorophenyl)-1H-pyrazole

生成物 1

HCID 866860843-(4-Fluoro-3-methyl-phenyl)-5-phenyl-pyrazol-1-yl-acetic acid methyl ester

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

3.6 g 3,5-Bis-(4-fluoro-phenyl)-1H-pyrazole, 8.8 g K2CO3 and 1.34 mL 2-bromoacetic acid methyl ester were dissolved in 100 mL acetone and stirred over night under reflux. K2CO3 was filtered and the solvent was removed. The residue was purified by HPLC (method 1) to yield 2.6 g of the desired product.

後処理

  1. temperatureunder reflux
  2. filtrationK2CO3 was filtered
  3. customthe solvent was removed
  4. customThe residue was purified by HPLC (method 1)

出典と根拠

ORDレコード
ord-1ee8bcbcedf74419965b116b64dfc881
出典データセット
uspto-grants-2014_06
特許番号
US08741892B2

反応ノート

読み込み中…