化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → HCID 71586646、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | (3,5-Diphenyl-pyrazol-1-yl)-acetic acid | HCID 824607 | — |
| 反応物 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 反応物 | 5-Chloro-2-(4-piperidinyl)pyrimidine | HCID 55262357 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Methanol--water (1/1) | HCID 22242641 | — |
| 生成物 | HCID 71586646 | HCID 71586646 | 23.9% |
反応手順
28 mg (3,5-diphenyl-pyrazol-1-yl)-acetic acid was dissolved in 2 mL DMF and 26 mg DIPEA and 32 mg TBTU were added to this solution and the reaction was stirred for 5 minutes at RT. The mixture was added to 20 mg 5-chloro-2-piperidin-4-ylpyrimidine and stirred for 2 h. The reaction was cleaned by RP-chromatographie (methanol/water, 0.1% NH3) to yield 11 mg of the desired compound. Rt: 2.38 (method A), (M+H)+: 458
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08741892B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-49ba1563701549929f09c701a9524617 |
| 出典メモ | uspto-grants-2014_06 |