4-Aminopyridazine → 3-Bromopyridazin-4-amine

HRID 400582

反応式

HRID 400582 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([NH2:7])=[CH:3][N:2]=1.[NH2:8][C:9]1C=C(C)[N:12]=[C:11]([CH3:16])[C:10]=1[Br:17]>>[NH2:7][C:4]1[CH:5]=[CH:6][N:1]=[N:2][C:3]=1[Br:17].[NH2:16][C:11]1[C:10]([Br:17])=[CH:9][N:8]=[N:1][CH:12]=1

参加物

4

反応物 2

HCID 2984924-AminopyridazineHCID 105122623-Bromo-2,6-dimethyl-4-pyridinamine

生成物 2

HCID 534853563-Bromopyridazin-4-amine収率 15%HCID 600266675-Bromopyridazin-4-amine収率 5%

実験手順

Bromination of pyridazin-4-ylamine was performed in the same manner as for the preparation of 4-amino-3-bromo-2,6-dimethylpyridine. Chromatography on SiO2 (20% ethyl acetate in hexanes to 100% ethyl acetate, gradient, followed by 2% methanol in ethyl acetate) yielded 4-amino-3-bromopyridazine (first eluting: 15% yield) and 4-amino-5-bromopyridazine (second eluting: 5% yield) as tan solids.

出典と根拠

ORDレコード
ord-78679f8e8f5a425f8e797a1019a0471e
出典データセット
uspto-grants-2014_06
特許番号
US08741897B2

関連ノート

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