5-tert-Butyl-3-(2-chloro-benzyl)-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidine → 5-tert-Butyl-3-(2-chloro-benzyl)-7-(6-oxa-1-aza-spiro[3.3]hept-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine

関与物質

反応手順

In analogy to the procedure described for the synthesis of 5-tert-butyl-3-(2-chloro-benzyl)-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidine (example 1, step c), the title compound was prepared from 5-tert-butyl-7-chloro-3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and 6-oxa-1-azaspiro[3.3]heptane oxalate and isolated as light-yellow gum (12.5 mg, 65%). MS (m/e): 399.4 (MH+).

情報源と証拠